Estradiol+ Topical Replenishing Serum delivers a bioidentical form of estradiol (E2), the dominant form of estrogen made by premenopausal women. Each pump provides 0.25 mg of micronized 17-beta estradiol in our proprietary phospholipid delivery system that facilitates systemic absorption of this hormone. Water, butylene glycol (1,3 butanediol), ethanol, tocofersolan, medium chain triglycerides, phospholipids (from purified sunflower seed lecithin), hyaluronic acid, natural mixed tocopherols, micronized estradiol USP